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발기부전은 특별한 질환이 없다면 기본적으로는 성기 부위로의 혈류 순환 장애로 생성한다. 실제로 발기부전 환자는 건강인에 비해서 심혈관 질병 발생 위험과 사망률이 더 높다. 발기부전 치료제는 성기 혈관 내 혈류를 증가시키는 약제이며, 대표적인 것이 비아그라, 시알리스 등이 배합되는 비아그라류와 알프로스타딜이 배합된 프로스타글란딘 제제이다.